Download Aldo-Keto Reductases and Toxicant Metabolism by Trevor M. Penning, J. Mark Petrash PDF

By Trevor M. Penning, J. Mark Petrash

content material: part 1: basic review ; 1. creation and evaluation of the Aldo-Keto Reductase (AKR) Superfamily ; part 2: AKRS AND ENDOGENOUS TOXICANTS ; 2. Aldo-Keto Reductase-Catalyzed Detoxication of Endogenous Aldehydes linked to Diabetic issues ; three. Aldose Reductase Detoxifies Lipid Aldehydes and Their Glutathione Conjugates ; four. position of Aldose Reductase within the cleansing of Oxidized Phospholipids ; part three: AKRS AND EXOGENOUS TOXICANTS: TOBACCO comparable cancer agents ; five. Competing Roles of Reductases within the detoxing of the Tobacco-Specific Nitrosamine Ketone NNK ; 6. Aldo-Keto Reductases and the Metabolic Activation of Polycyclic fragrant Hydrocarbons ; 7. Molecular Cloning and Characterization of Dihydrodiol Dehydrogenase from Mouse ; eight effective Synthesis of the energetic Metabolites of Carcinogenic Polycyclic fragrant Hydrocarbons ; nine. Chemistry of PAH o-Quinones Generated by way of the AKR Pathway of PAH Activation ; 10. research of Etheno-2'-Deoxyguanosine Adducts as Dosimeters of AKR Mediated Oxidative tension ; part four: AKRS AND EXOGENOUS TOXICANTS: MYCOTOXINS, ALDEHYDES AND KETONES ; eleven. Aflatoxin Aldehyde Reductases ; 12. Competing Reactions of Aflatoxin B1-Dialdehyde: Enzymatic aid vs Adduction with Lysine ; thirteen. using mammalian mobilephone strains to enquire the function of aldo-keto reductases within the detoxication of aldehydes and ketones ; part five: AKRS, the tension reaction AND telephone SIGNALING ; 14. Aldose Reductase and the tension reaction ; 15. Aldose Reductase Regulates Reactive Oxygen Species Mediated-Inflammatory signs ; sixteen. Aldo-Keto Reductases within the rigidity reaction of the Budding Yeast Saccharomyces cerevisiae

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